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Research Project

Measures for Improved Availability of medicines and vaccines (MIA)

Ensuring availability of essential medicines, vaccines and health commodities is one of today’s critical societal challenges

The MIA project 2020-2024

BI Norwegian Business School, INSEAD, Jimma University, Lancaster University, Norwegian Institute of Public Health, Rotterdam School of Management, St. Paul's Hospital Millennium Medical College

Objectives and background

Ensuring availability of essential medicines and vaccines is one of today’s critical societal challenges. While the COVID-19 pandemic exposed the vulnerability of medicine supply chains at full scale, medicine shortages were already an increasing global problem in normal times before the pandemic, particularly off-patent (i.e. generic) medicine shortages. When medicine supply chains break down, it can lead to serious injury and death. The primary objective of MIA was to help key stakeholders make evidence-based decisions that sustainably reduce medicine and vaccine shortages, addressing a key societal challenge to ensure future health and care services.  Secondary objectives were:

  1. To contribute to improved supply security, i.e. access to medicine and vaccine services in Norway and the UK.
  2. To provide policy makers and other key stakeholders with a holistic and rigorous analysis of the direct and indirect costs and benefits of measures for enhanced supply security, thus contributing to more efficient and effective health services.
  3. To provide a basis for comparative studies in other countries by developing baseline data, research design protocols, and analytical and pedagogical models and tools. 

Results achieved

Our research shows that although policymakers discussed strategies to address shortages, few had implemented them by the time the pandemic struck. There is increased governmental interest in the vulnerability of supply and the level of preparedness. However, the numerous stakeholders differ in goals and incentives in terms of focusing cost, quality, service, and/or sustainability. The supply chains are complex with many global actors involved. Furthermore, supply chains are vulnerable due to specialization, few buffers, and outsourcing to low-cost countries. Focus on low prices for generics, while reducing public spending for medicine and improving access for more people, has led to many medicines with very few suppliers. This, in addition to lack of transparency and information sharing, means that fixing the causes of shortage problems is easier said than done. Particularly we provide knowledge concerned with the type of interventions used to avoid shortages in normal and abnormal times and the role of policymakers in selecting and implementing these interventions. We have brought the government perspective into OSCM and vice versa and demonstrated the need for a cross-disciplinary approach to medicine shortage. We have provided insights on how to prepare medicine and medical equipment supply chains for future epidemics/pandemics in the long-term and presented practical conclusions and implications with recommendations for policymakers and direct supply chain members. A key finding is the need to combine preparedness with adaptability in response through process modularity; resource interaction in cross-sectorial/disciplinary collaboration; the interplay between temporary and permanent organizing; the use of a mixed set of risk mitigation strategies and differentiation depending on drug characteristics beyond medical criticality. Policymakers can use our frameworks, tools and findings to improve the availability of generic medicines in (ab)normal times. To answer the research questions, we conducted the following sub-projects:

Most important R&D tasks conducted including researcher groups

The project combined expertise from Operations and Supply Chain Management (OSCM) with global/public health, and pharmacy for the purpose of providing policymakers with evidence-based decision-support, data, and tools. The core team consisted of one researcher from the Norwegian Institute of Public Health, 3 from BI Norwegian Business School (OSCM), 2 from RSM (OSCM), 2 from Lancaster (OSCM), 3 from INSEAD (OSCM) and 3 from Jimma University (Pharmacy/Public Health). All studies were set up in collaboration between two or more partners and made use of mixed research methods combining qualitative (for example through news reports, interviews, and surveys) and quantitative (stock reports, databases, and evaluation reports) data with modelling such as simulation and optimization. All studies had different types of outputs including tools, reports, scientific presentations and publications, teaching and dissemination to users and the general public.

Assessment of project implementation and use of resources

Each sub-project was set up with a project leader using project planning tools and calling for frequent zoom meetings. Due to the pandemic, it took 1,5 years before we could have a physical meeting between the participants. It was quite challenging and resource demanding to get to know one another and setting up the communication/collaboration structure in each sub-project in the beginning. The co-authoring of papers and reports was done by using e-mail and dropbox-folders and worked quite well because responsibilities were clear, and sub-project leaders followed up. All sub-projects were completed. Substantial data were collected in all studies despite challenges related to the pandemic. Due to the pandemic, less travelling between the partner institutions and to conferences took place. 

Research stays abroad & contribution

One researcher from Lancaster to BI for 1 month resulted in important progress of one of the papers and a draft of a new research proposal for continued funding. One researcher from Jimma to BI for 1 month allowed for exchange of knowledge from pharmacy to OSCM and transfer of knowledge regarding approaches, models and tools developed in the MIA-project to LMIC.

Anticipated significance/benefits of results

Plans for further dissemination and utilization of results

Our 20 peer-reviewed international articles have been published in 18 different journals in OSCM, disaster management and health and already created a lot of scientific impact. We have trained master students in OSCM and pharmacy by supervising in total 21 MSc-theses in UK, Netherlands, and Norway. We have also disseminated results from the project in bachelor, master, and executive teaching programs. We have conducted more than 50 workshops and seminars with users, and have close to 50 popularized articles, see The MIA Project. We will continue dissemination and use of results, for example through supervision of PhD students, continued interaction with stakeholders and other researchers. A European Researcher network on medicine supply chains is in the making, with the two first workshops conducted in 2024.

Expected results to be finalized after project completion

Numerous propositions and suggestions for future research opportunities have been developed. Additional 10 scientific publications are either under revision, under review in journals or under development. Participants continue to develop new papers for presentation at conferences. Interaction with stakeholders continues. We have acquired funding for two postdocs and one PhD student who will continue to work based on MIA-results and data for another 4 years. New proposals for additional funding are under development.

Participants from BI

Useful links